Trifluoroacetic acid → HCID 10454402, compound

HRID 349462Notes

Reaction equation

HRID 349462 reaction equation
C([O:5][C:6](=[O:35])[C:7]1[CH:12]=[CH:11][C:10]([CH2:13][N:14]2[N:18]=[N:17][C:16]([C:19]3[CH:20]=[N:21][CH:22]=[C:23]([C:25]#[C:26][CH2:27][C:28]4[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=4)[CH:24]=3)=[N:15]2)=[CH:9][CH:8]=1)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[F:34][C:31]1[CH:32]=[CH:33][C:28]([CH2:27][C:26]#[C:25][C:23]2[CH:24]=[C:19]([C:16]3[N:17]=[N:18][N:14]([CH2:13][C:10]4[CH:9]=[CH:8][C:7]([C:6]([OH:35])=[O:5])=[CH:12][CH:11]=4)[N:15]=3)[CH:20]=[N:21][CH:22]=2)=[CH:29][CH:30]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68978997HCID 68978997, compound

Product 1

HCID 10454402HCID 10454402, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The product of Step (c) was treated with trifluoroacetic acid in dichloromethane in a manner analogous to that described above in Step (c) of Example 43, then rotary evaporated in vacuo. Trituration of the resulting oil with diethyl ether gave the title product (84 mg, 78%). 1H NMR (DMSO-d6) δ 13.0 (s, 1H), 9.13 (s, 1H), 8.78 (s, 1H), 8.36 (s, 1H), 7.93 (d, J=8 Hz, 2H), 7.50 (d, J=8 Hz, 2H), 7.45 (m, 2H), 7.17 (m, 2H), 6.13 (s, 2H), 3.95 (s, 2H).

Workup

  1. customrotary evaporated in vacuo

Sources & evidence

ORD record
ord-901fcf7919be4fdb98d15eac3a21fa67
Source dataset
uspto-grants-2007_02
Patent number
US07179822B2

Reaction notes

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