Hydrochloric Acid → 5-bromo-N-(2-aminoethyl)-2-thiophenecarboxamide hydrochloride

HRID 34947Notes

Reaction equation

HRID 34947 reaction equation
[NH:1]([CH2:5][CH2:6][NH:7][C:8]([C:10]1[S:11][C:12]([Br:15])=[CH:13][CH:14]=1)=[O:9])C(C)=O.[ClH:16]>>[ClH:16].[Br:15][C:12]1[S:11][C:10]([C:8]([NH:7][CH2:6][CH2:5][NH2:1])=[O:9])=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 2604169N-(2-acetamidoethyl)-5-bromothiophene-2-carboxamide

Product 1

HCID 138002765-bromo-N-(2-aminoethyl)-2-thiophenecarboxamide hydrochloride

Procedure

N-(2-Acetaminoethyl)-5-bromo-2-thiophenecarboxamide was reacted with hydrochloric acid in an analogous manner to that described in Example 1, paragraph 3. The residue was dissolved in alcohol (pH 1), filtered and concentrated to about 300 ml under reduced pressure. After cooling to 5° the product was filtered off under suction and dried, whereby 5-bromo-N-(2-aminoethyl)-2-thiophenecarboxamide hydrochloride was obtained as white crystals, m.p. 221°-222°, after recrystallization from ethanol.

Workup

  1. filtrationfiltered
  2. concentrationconcentrated to about 300 ml under reduced pressure
  3. temperatureAfter cooling to 5° the product
  4. filtrationwas filtered off under suction
  5. customdried

Sources & evidence

ORD record
ord-54ae05bc05c541b0a898ca7dc86540e6
Source dataset
uspto-grants-1988_08
Patent number
US04764522

Reaction notes

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