反应详情

tert-Butyl (2S)-2-((3S)-3-{[(6-chloro-2-naphthyl)sulfonyl]amino}-2-oxopyrrolidin-1-yl)propanoate (0.643 g) was dissolved in DCM (19 ml), and trifluoroacetic acid (19 ml) was added. The mixture was stirred at room temperature for 2.5 h and then concentrated under reduced pressure. Anhydrous DCM (4 ml) was added and the solution evaporated under reduced pressure. Repetitive addition of DCM and concentration under reduced pressure provided the title compound (0.56 g) as a white foam.

1. concentrationconcentrated under reduced pressure
2. additionAnhydrous DCM (4 ml) was added
3. customthe solution evaporated under reduced pressure
4. additionRepetitive addition of DCM and concentration under reduced pressure