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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 34954Generated: October 30, 2026

Cyanogen Bromide → 8alpha-Benzyloxycarbonylamino-6-cyanoergoline

https://huagongshe.com/reaction/34954

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCyanogen BromideHCID 10476—
Reactant8alpha-Benzyloxycarbonylamino-6-methylergolineHCID 70417848—
SolventChloroformHCID 6212—
Product8alpha-Benzyloxycarbonylamino-6-cyanoergolineHCID 86742331—

Reaction Steps

A solution of 29.5 g (79 mM) of 8α-benzyloxycarbonylamino-6-methylergoline obtained from step (a) and 25 g (236 mM) cyanobromide in 600 ml chloroform is stirred for 65 hours at room temperature and finally concentrated on a rotary evaporator to give the heading compound which is dried in a high vacuum.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04764517
Source datasetuspto-grants-1988_08
ORD IDord-14c84d7a4a1b47bda48304e6557ddf00
Source noteuspto-grants-1988_08