反应详情

温度

60 °C

To a solution of 5-amino-1-isopropyl-1H-pyrazole-4-carbonitrile (10.4 g) in pyridine (200 ml) was added triphenylmethyl chloride (23.2 g) at room temperature. The mixture was stirred at 60° C. for 5 hours. The reaction mixture was evaporated under reduced pressure and extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate, filtered, and evaporated vacuo. The residue was triturated with diisopropyl ether to give 1-isopropyl-5-tritylamino-1H-pyrazole-4-carbonitrile (19.1 g).

1. customThe reaction mixture was evaporated under reduced pressure
2. extractionextracted with ethyl acetate
3. dry with materialThe extract was dried over anhydrous magnesium sulfate
4. filtrationfiltered
5. customevaporated vacuo
6. customThe residue was triturated with diisopropyl ether