反应详情

温度

60 °C

To a suspension of 5-amino-1-propyl-1H-pyrazole-4-carbonitrile (16.32 g) in pyridine (160 ml) was added triphenylmethyl chloride (36.35 g) at room temperature. After stirring at 60° C. for 5 hours, the reaction mixture was evaporated in vacuo. The residue was added to a mixture of tetrahydrofuran and brine, and the organic layer was separated and washed with brine. The extract was dried over anhydrous magnesium sulfate, filtered, and evaporated in vacuo. To the residue was triturated with diisopropyl ether to give 1-propyl-5-tritylamino-1H-pyrazole-4-carbonitrile (37.21 g) as a colorless solid.

1. customthe reaction mixture was evaporated in vacuo
2. additionThe residue was added to a mixture of tetrahydrofuran and brine
3. customthe organic layer was separated
4. washwashed with brine
5. dry with materialThe extract was dried over anhydrous magnesium sulfate
6. filtrationfiltered
7. customevaporated in vacuo
8. customTo the residue was triturated with diisopropyl ether