反应详情

To a suspension of lithium aluminum hydride (8.94 g) in tetrahydrofuran (600 ml) was added 1-propyl-5-tritylamino-1H-pyrazole-4-carbonitrile (37 g) at room temperature. The mixture was refluxed for 7 days. After cooling on an ice bath, sodium fluoride (40 g) and water (17 ml) were added to the reaction mixture. The insoluble materials were removed by filtration. To the filtrate was added ethyl formate, and the mixture was refluxed for 24 hours. After evaporation of the solvent in vacuo, the residue was triturated with diisopropyl ether and dried in vacuo to give 4-aminomethyl-1-propyl-5-tritylaminopyrazole (30.3 g).

1. temperatureThe mixture was refluxed for 7 days
2. temperatureAfter cooling on an ice bath
3. customThe insoluble materials were removed by filtration
4. additionTo the filtrate was added ethyl formate
5. temperaturethe mixture was refluxed for 24 hours
6. customAfter evaporation of the solvent in vacuo
7. customthe residue was triturated with diisopropyl ether
8. customdried in vacuo