反应详情

温度

60 °C

To a solution of 5-amino-1-(2-hydroxyethyl)-1H-pyrazole-4-carbaldehyde (40.2 g) in pyridine (400 ml) was added triphenylmethyl chloride (86.7 g) at room temperature. The mixture was stirred at 60° C. for 5 hours. The reaction mixture was evaporated under reduced pressure and extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate, filtered, and evaporated in vacuo. The residue was purified by column chromatography on silica gel eluting with ethyl acetate/hexane (3:2) to give 5-amino-1-(2-triphenylmethyloxyethyl)-1H-pyrazole-4-carbaldehyde (62.8 g).

1. customThe reaction mixture was evaporated under reduced pressure
2. extractionextracted with ethyl acetate
3. dry with materialThe extract was dried over anhydrous magnesium sulfate
4. filtrationfiltered
5. customevaporated in vacuo
6. customThe residue was purified by column chromatography on silica gel eluting with ethyl acetate/hexane (3:2)