Ethyl formate → 2-(2,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)ethylformamide

HRID 349571Notes

Reaction equation

HRID 349571 reaction equation
[NH:1]1[C:8]2[N:4]([N:5]=[CH:6][C:7]=2[CH2:9][CH2:10][NH2:11])[CH2:3][CH2:2]1.[CH:12](OCC)=[O:13]>>[NH:1]1[C:8]2[N:4]([N:5]=[CH:6][C:7]=2[CH2:9][CH2:10][NH:11][CH:12]=[O:13])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 8025Ethyl formateHCID 1357327622-(2,3-Dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)ethanamine

Product 1

HCID 1363341052-(2,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)ethylformamide

Procedure

A suspension of 2-(2,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)ethylamine (155 mg) in ethyl formate (3 ml) was refluxed for 4.5 hours. After evaporation of the solvent in vacuo, the residue was triturated with ethyl acetate and dried in vacuo to give 2-(2,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)ethylformamide (165 mg) as a solid.

Workup

  1. temperaturewas refluxed for 4.5 hours
  2. customAfter evaporation of the solvent in vacuo
  3. customthe residue was triturated with ethyl acetate
  4. customdried in vacuo

Sources & evidence

ORD record
ord-20db1619b3a544cd8dc99178597891e5
Source dataset
uspto-grants-2007_02
Patent number
US07179801B2

Reaction notes

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