Ammonia → HCID 135732766, compound

HRID 349574Notes

Reaction equation

HRID 349574 reaction equation
C([N:3]1[C:10]2[N:6]([N:7]=[CH:8][C:9]=2[CH2:11][CH2:12][C:13]([O:15]CC)=O)[CH2:5][CH2:4]1)=O.[NH3:18]>CO>[NH:3]1[C:10]2[N:6]([N:7]=[CH:8][C:9]=2[CH2:11][CH2:12][C:13]([NH2:18])=[O:15])[CH2:5][CH2:4]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 17961982HCID 17961982, compound

Product 1

HCID 135732766HCID 135732766, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of ethyl 3-(1-formyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)propanoate (10 g) in a mixture of methanol (50 ml) and an aqueous solution of 28% ammonia (104 ml) was stirred at room temperature for 41 hours. After evaporation of the solvent in vacuo, the residue was triturated with diisopropyl alcohol, dried in vacuo to give 3-(2,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)propanamide (6.44 g).

Workup

  1. customAfter evaporation of the solvent in vacuo
  2. customthe residue was triturated with diisopropyl alcohol
  3. customdried in vacuo

Sources & evidence

ORD record
ord-ceae100c828348db9b1f4093069dc5cc
Source dataset
uspto-grants-2007_02
Patent number
US07179801B2

Reaction notes

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