HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorotrimethylsilane → Methyl 4-methoxy-2-(1-methylethoxy)-3-(trimethylsilyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | Methyl 2-isopropoxy-4-methoxybenzoate | HCID 14276512 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Methyl 4-methoxy-2-(1-methylethoxy)-3-(trimethylsilyl)benzoate | HCID 14276513 | — |
Reaction Steps
More specifically, Scheme 3 shows compound of the formula 9 is prepared by adding a mixture methyl 4-methoxy-2-(l-methylethoxy)benzoate of the formula (10) and chlorotrimethylsilane to a -70° C. -78° C. tetrahydrofuran solution of lithium diisopropylamide to give methyl 4-methoxy-2-(1-methylethoxy)-3-(trimethylsilyl)benzoate (11) regioselectively.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04764525 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-40ec61ce8c2f496c85fcb741cdbab0f2 |
| Source note | uspto-grants-1988_08 |