反应详情

A solution of 1.6 g. of 5-(2-propyl-3,4dichlorophenoxy)pentyl bromide and 0.22 g. of sodium cyanide were heated overnight at 75°-85° C. in 50 ml. of dimethylformamide. The solution was evaporated in vacuo and ethyl acetate and water were added to the residue. The layers were separated and the organic layer was washed several times with a saturated sodium chloride solution. The organic solution was filtered through sodium sulfate and evaporated to dryness to give 1.38 g. of the desired sub-title intermediate. NMR.

1. customThe solution was evaporated in vacuo and ethyl acetate and water
2. additionwere added to the residue
3. customThe layers were separated
4. washthe organic layer was washed several times with a saturated sodium chloride solution
5. filtrationThe organic solution was filtered through sodium sulfate
6. customevaporated to dryness
7. customto give 1.38 g