反应详情

A solution of 0.5 g. of 4-(2-propyl-3- chloro-4-acetylphenoxy)butane nitrile and 1.3 g. of tetramethylguanidinium azide in 3 ml. of dimethylformamide was heated overnight at 125° C. The reaction was cooled, ethyl acetate and water were added, and the layers were separated. Water was added to the ethyl acetate layer, the water layer was acidified, and the layers were separated. The ethyl acetate was dried and evaporated to dryness. The residue was purified by chromatography to give the desired title product. NMR.

1. temperatureThe reaction was cooled
2. customthe layers were separated
3. additionWater was added to the ethyl acetate layer
4. customthe layers were separated
5. dry with materialThe ethyl acetate was dried
6. customevaporated to dryness
7. customThe residue was purified by chromatography