Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → 5-[4-(2-Propyl-3-chloro-4-acetylphenoxy)butyl]-tetrazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | 4-(2-Propyl-3-chloro-4-acetylphenoxy)butane nitrile | HCID 21297263 | — |
| 반응물 | HCID 178484365 | HCID 178484365 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 5-[4-(2-Propyl-3-chloro-4-acetylphenoxy)butyl]-tetrazole | HCID 178439676 | — |
반응 단계
A solution of 0.5 g. of 4-(2-propyl-3- chloro-4-acetylphenoxy)butane nitrile and 1.3 g. of tetramethylguanidinium azide in 3 ml. of dimethylformamide was heated overnight at 125° C. The reaction was cooled, ethyl acetate and water were added, and the layers were separated. Water was added to the ethyl acetate layer, the water layer was acidified, and the layers were separated. The ethyl acetate was dried and evaporated to dryness. The residue was purified by chromatography to give the desired title product. NMR.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04764521 |
| 출처 데이터셋 | uspto-grants-1988_08 |
| ORD ID | ord-7298b72149514b3780afca07e5e83947 |
| 출처 메모 | uspto-grants-1988_08 |