反应详情

Six grams of 2-propylresorcinol and 6.4 g. of 5-bromovaleronitrile were reacted following cedure of Example 2A to provide 3.4 g. of the desired nitrile intermediate. This intermediate was heated to 125° C. overnight with 40 mmoles of tetramethylguanidinium azide in 10 ml. of dimethylformamide. The solvent was removed under reduced pressure and the residue was dissolved in ethyl acetate. The organic solution was washed with water adjusted to pH 6. The organic layer was dried and evaporated to yield the desired subtitle tetrazole intermediate which crystallized after evaporation of the solvent. NMR.

1. customto provide 3.4 g
2. customThe solvent was removed under reduced pressure
3. dissolutionthe residue was dissolved in ethyl acetate
4. washThe organic solution was washed with water
5. customThe organic layer was dried
6. customevaporated