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HRID349762

反应详情

EQUATION

反应方程式

HRID 349762 的结构方程式

REACTANTS

反应物

2
结构：C=C(C(=O)O)c1ccccc1
HCID68114

Benzeneacetic acid, .alpha.-methylene-

C9H8O2

结构：CC(C)(C)OC(=O)N1CCNCC1
HCID143452

tert-Butyl piperazine-1-carboxylate

C9H18N2O2

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1CCN(CC(C(=O)O)c2ccccc2)CC1
HCID45588421

4-[(1,1-Dimethylethoxy)carbonyl]-α-phenyl-1-piperazinepropanoic acid

C18H26N2O4

收率 54.3%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)O
溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

Piperazine-1-carboxylic acid tert-butyl ester (17.43 g) and 2-phenylacrylic acid (18 g) in iso-propanol (500 ml) was heated at reflux for four days. The resulting precipitate was filtered, washed with diethyl ether and dried under vacuum to give the title compound as a white solid (17 g; MS: APCI+(M+H) 335).

WORKUP

后处理

  1. temperatureat reflux for four days
  2. filtrationThe resulting precipitate was filtered
  3. washwashed with diethyl ether
  4. customdried under vacuum