反应详情

A solution of 3.09 g. of 2-propyl-3,4-dichlorophenol, 3.1 g. of 7-bromoheptanoic acid, 3.1 g. of potassium carbonate, and 2.0 g. of potassium iodide in 50 ml. of methyl ethyl ketone was heated at reflux overnight. The reaction mixture was cooled to room temperature and evaporated in vacuo. Ethyl acetate and water were added to the residue and the layers were separated. Fresh water was added to the organic layer, the pH was adjusted to 2.0 with acid, and the layers were separated. The organic layer was washed with a saturated sodium chloride solution, filtered through sodium sulfate, and evaporated to dryness to give 4.68 g. of the desired title product.

1. temperatureat reflux overnight
2. customevaporated in vacuo
3. additionEthyl acetate and water were added to the residue
4. customthe layers were separated
5. additionFresh water was added to the organic layer
6. customthe layers were separated
7. washThe organic layer was washed with a saturated sodium chloride solution
8. filtrationfiltered through sodium sulfate
9. customevaporated to dryness
10. customto give 4.68 g