HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Codeine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Morphine | HCID 5288826 | — |
| Catalyst | Phenyltrimethylammonium chloride | HCID 67309 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Codeine | HCID 5284371 | 95.6% |
Reaction Steps
Morphine of 89.0% purity 320 parts (1 mole part), potassium carbonate 552 parts (4 moles part), water 65 parts and trimethylphenylammonium chloride 188 parts (1.1 moles part) are heated under stirring in toluene (4000 parts) at 45° to 120° C. for 2 to 8 hrs. to yield 296 parts codeine (95.6% yield after workup as in Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04764615 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-de6aa70261ab4783b10797d3fce05e0e |
| Source note | uspto-grants-1988_08 |