反应详情

A mixture of ethyl(E)-3-[1-(4-benzyloxybenzyl)-4-phenyl-3-pyrrolyl]propenoate (19.50 g), 5% palladium-carbon (20.00 g), and tetrahydrofuran (200 ml) was stirred overnight at room temperature under a hydrogen atmosphere. After the palladium-carbon was removed by filtration, the filtrate was concentrated. The residue was subjected to silica gel column chromatography, and ethyl 3-[1-(4-hydroxybenzyl)-4-phenyl-3-pyrrolyl]propionate (14.92 g, yield: 96%) was obtained as an oily substance from the fraction eluted with ethyl acetate-hexane (1:2, volume ratio).

1. customAfter the palladium-carbon was removed by filtration
2. concentrationthe filtrate was concentrated