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HRID34989

反应详情

EQUATION

反应方程式

HRID 34989 的结构方程式

REACTANTS

反应物

2
结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5
HCID5288826

Morphine

C17H19NO3

PRODUCTS

生成物

1
结构：COc1ccc2c3c1O[C@H]1[C@@H](O)C=C[C@H]4[C@@H](C2)N(C)CC[C@@]341
HCID5284371

Codeine

C18H21NO3

收率 99%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：C[N+](C)(C)c1ccccc1.[Cl-]
催化剂HCID67309

未命名化合物

结构：Cc1ccccc1
溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

Morphine of purity 35% 815 parts (1 mole parts), potassium carbonate 552 parts (4 moles part) and trimethylphenyl-ammonium chloride 188 parts (1.1 moles part) are heated under stirring in toluene (5000 parts) at 45° to 120° C. for 2 to 5 hrs. to yield 296 parts codeine (99% yield), after workup as in Example 1.