反应详情

A mixture of ethyl(E)-3-[1-(6-benzyloxy-2-naphthylmethyl)-4-phenyl-3-pyrrolyl]propenoate (1.46 g), 5% palladium-carbon (1.5 g), ethanol (15 ml), and tetrahydrofuran (15 ml) was stirred for 4 hours at room temperature under a hydrogen atmosphere. After the palladium-carbon was removed by filtration, the filtrate was concentrated. The residue was subjected to silica gel column chromatography, and ethyl 3-[1-(6-hydroxy-2-naphthylmethyl)-4-phenyl-3-pyrrolyl]propionate (1.08 g, yield: 90%) was obtained as an oily substance from the fraction eluted with ethyl acetate-hexane (1:1, volume ratio).

1. customAfter the palladium-carbon was removed by filtration
2. concentrationthe filtrate was concentrated