反应详情

A mixture of (1-benzyl-3-benzyloxy-1H-pyrazol-4-yl)methanol (14.70 g), activated manganese dioxide (30.00 g), and tetrahydrofuran (200 ml) was stirred at room temperature for 2 hours. After the manganese dioxide was removed by filtration, the filtrate was concentrated. The crystals obtained were collected by filtration to yield 1-benzyl-3-benzyloxy-1H-pyrazole-4-carbaldehyde (13.10 g, yield: 90%). This was recrystallized from tetrahydrofuran-hexane. Melting point: 85–86° C.

1. customAfter the manganese dioxide was removed by filtration
2. concentrationthe filtrate was concentrated
3. customThe crystals obtained
4. filtrationwere collected by filtration