反应详情

31.5 g (0.08 mol) of ethyl 2-benzylthio-1-(2,6-diethylphenyl)-imidazole-5-carboxylate (cf. Example 2) were stirred with 30 g of 33% strength sodium hydroxide solution at 80° C. until a homogeneous solution was formed. The solution was allowed to cool and acidified to pH 3 with dilute hydrochloric acid, and the product was filtered off under suction and dried in vacuo. 26.4 g (90% of theory) of 2-benzylthio-1-(2,6-diethylphenyl)-imidazole-5-carboxylic acid, solid at melting point 152°-154° C., were obtained.

1. customwas formed
2. temperatureto cool
3. filtrationthe product was filtered off under suction
4. customdried in vacuo