HCID 23512268, 화합물 → HCID 23512013, 화합물

HRID 350431노트

반응식

HRID 350431 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][C:10](=[O:24])[NH:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][C:19]([O:21]CC)=[O:20])=[CH:14][CH:13]=1>C1COCC1.[OH-].[Na+]>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][C:10](=[O:24])[NH:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][C:19]([OH:21])=[O:20])=[CH:14][CH:13]=1

참가 물질

4

반응물 1

HCID 23512268HCID 23512268, 화합물

생성물 1

HCID 23512013HCID 23512013, 화합물수율 82.8%

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 14798Sodium Hydroxide용매

실험 절차

To a stirred solution of ethyl 4-[N′-(2,6-dichlorophenyl)ureido]phenylacetate (3.19 g, 8.69 mmol) in THF (70 ml), 0.25 N NaOH (70 ml) was added. After stirring at room temperature for 17 h, the solvent was concentrated in vacuo. The residue was triturated by the addition of water, to give 4-[N′-(2,6-dichlorophenyl)ureido]phenylacetic acid (2.44 g, 82%) as colorless powder. mp 262–263° C. (dec.); 1H-NMR (DMSO-d6) δ 3.48 (s, 2H), 7.14 (d, J=8.3 Hz, 2H), 7.31 (t, J=8.3 Hz, 1H), 7.37 (d, J=8.3 Hz, 2H), 7.52 (d, J=8.0 Hz, 2H), 8.18 (s, 1H), 8.90 (s, 1H), 12.22 (br, 1H); MS (ESI) m/z 339 (M++1), 341 (M++3), 343 (M++5).

후처리

  1. concentrationthe solvent was concentrated in vacuo
  2. customThe residue was triturated by the addition of water

출처 및 근거

ORD 기록
ord-be87960e66bf453dbb9dab42d63e5071
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07179819B2

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