反应详情

3-Benzyloxy-4-methoxy-4′-phenoxypicolinanilide (0.64 g, 1.5 mmol) was mixed with ethanol (4 ml) to prepare a suspension. To this suspension was added 64 mg of 10% palladium-carbon. The mixture was subjected to catalytic reduction under atmospheric conditions overnight. The reaction solution was filtered, and the filtrate was concentrated under the reduced pressure. The residue was dissolved in a water-methanol mixed solution, and was recrystallized to give 0.41 g (yield 81%) of the title compound.

1. customto prepare a suspension
2. customwas subjected to catalytic reduction under atmospheric conditions overnight
3. filtrationThe reaction solution was filtered
4. concentrationthe filtrate was concentrated under the reduced pressure
5. dissolutionThe residue was dissolved in a water-methanol mixed solution
6. customwas recrystallized