3-Benzyloxy-4-methoxy-4'-phenoxypicolinanilide → 3-Hydroxy-4-methoxy-4'-phenoxypicolinanilide

Participants

Reaction Steps

3-Benzyloxy-4-methoxy-4′-phenoxypicolinanilide (0.64 g, 1.5 mmol) was mixed with ethanol (4 ml) to prepare a suspension. To this suspension was added 64 mg of 10% palladium-carbon. The mixture was subjected to catalytic reduction under atmospheric conditions overnight. The reaction solution was filtered, and the filtrate was concentrated under the reduced pressure. The residue was dissolved in a water-methanol mixed solution, and was recrystallized to give 0.41 g (yield 81%) of the title compound.

Provenance & Evidence