HCID 17817671, compound → HCID 21088905, compound

HRID 350642Notes

Reaction equation

HRID 350642 reaction equation
C([O:8][C:9]1[C:10]([C:17]([NH:19][C:20]2[CH:25]=[CH:24][C:23]([O:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[CH:22][CH:21]=2)=[O:18])=[N:11][C:12]([O:15][CH3:16])=[CH:13][CH:14]=1)C1C=CC=CC=1>C(O)C.[C].[Pd]>[OH:8][C:9]1[C:10]([C:17]([NH:19][C:20]2[CH:25]=[CH:24][C:23]([O:26][C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)=[CH:22][CH:21]=2)=[O:18])=[N:11][C:12]([O:15][CH3:16])=[CH:13][CH:14]=1

Participants

4

Reactant 1

HCID 17817671HCID 17817671, compound

Product 1

HCID 21088905HCID 21088905, compoundYield 83%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

3-Benzyloxy-6-methoxy-4′-phenoxypicolinanilide was suspended in 5 ml of ethanol. 10% palladium-carbon (30 mg) was added to the suspension. The mixture was subjected to catalytic reduction under atmospheric conditions overnight. The reaction solution was filtered, and the filtrate was concentrated under the reduced pressure. The residue was then purified by column chromatography on silica gel (chloroform) to give the title compound (yield 83%).

Workup

  1. customwas subjected to catalytic reduction under atmospheric conditions overnight
  2. filtrationThe reaction solution was filtered
  3. concentrationthe filtrate was concentrated under the reduced pressure
  4. customThe residue was then purified by column chromatography on silica gel (chloroform)

Sources & evidence

ORD record
ord-4e869b2e1ac449d6a87c03c57fc4d859
Source dataset
uspto-grants-2007_02
Patent number
US07183278B1

Reaction notes

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