Hydrochloric Acid → 3-Benzyloxy-4,5-dimethoxypicolinic acid

HRID 350660Notes

Reaction equation

HRID 350660 reaction equation
[CH2:1]([O:8][C:9]1[C:10]([C:19]([O:21]C)=[O:20])=[N:11][CH:12]=[C:13]([O:17][CH3:18])[C:14]=1[O:15][CH3:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].Cl>CO>[CH2:1]([O:8][C:9]1[C:10]([C:19]([OH:21])=[O:20])=[N:11][CH:12]=[C:13]([O:17][CH3:18])[C:14]=1[O:15][CH3:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 17817675Methyl 3-benzyloxy-4,5-dimethoxypicolinate

Product 1

HCID 177986633-Benzyloxy-4,5-dimethoxypicolinic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl 3-benzyloxy-4,5-dimethoxypicolinate (20 mg) was dissolved in 1 ml of methanol. A 1 N aqueous sodium hydroxide solution (0.33 ml) was added to the solution, and a reaction was allowed to proceed at room temperature for 3 hr. The reaction solution was neutralized with 1 N hydrochloric acid, and was then concentrated under the reduced pressure to give the title compound.

Workup

  1. concentrationwas then concentrated under the reduced pressure

Sources & evidence

ORD record
ord-23c52be372134603a0d5dd7f914bdef4
Source dataset
uspto-grants-2007_02
Patent number
US07183278B1

Reaction notes

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