Hydrogen chloride-ethyl acetate → HCID 23061927, compound

HRID 350713Notes

Reaction equation

HRID 350713 reaction equation
[CH2:1]([S:3]([CH2:6][CH2:7][NH:8]C(=O)OC(C)(C)C)(=[O:5])=[O:4])[CH3:2].[ClH:16].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:16].[CH2:1]([S:3]([CH2:6][CH2:7][NH2:8])(=[O:5])=[O:4])[CH3:2]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 23061897HCID 23061897, compound

Product 1

HCID 23061927HCID 23061927, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a mixture of tert-butyl 2-(ethylsulfonyl)ethylcarbamate (1.5 g) and ethyl acetate (15 mL) was added dropwise 4N hydrochloric acid•ethyl acetate solution (4 mL) with stirring under ice-cooling. The mixture was stirred at room temperature for 4 hrs., and the precipitated crystals were collected by filtration and washed with ethyl acetate to give 2-(ethylsulfonyl)ethylamine hydrochloride as crystals. (0.76 g, yield 69%). Recrystallization from ethanol gave colorless prism crystals. melting point: 103–104° C.

Workup

  1. temperaturecooling
  2. stirringThe mixture was stirred at room temperature for 4 hrs
  3. filtration, and the precipitated crystals were collected by filtration
  4. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-5ad673ded10f4e2092fb6da2be4af033
Source dataset
uspto-grants-2007_02
Patent number
US07183276B2

Reaction notes

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