Diethyl Ether → HCID 20027838, compound

HRID 35072Notes

Reaction equation

HRID 35072 reaction equation
[CH2:1]([N:6]1[C:11](=[O:12])[CH:10]2[CH2:13][C:8]([C:14]3[CH:19]=[CH:18][C:17]([N+:20]([O-])=O)=[CH:16][CH:15]=3)([CH2:9]2)[C:7]1=[O:23])[C:2]([CH3:5])([CH3:4])[CH3:3].C(OCC)C>C(OCC)(=O)C.[Pd]>[NH2:20][C:17]1[CH:16]=[CH:15][C:14]([C:8]23[CH2:9][CH:10]([CH2:13]2)[C:11](=[O:12])[N:6]([CH2:1][C:2]([CH3:4])([CH3:3])[CH3:5])[C:7]3=[O:23])=[CH:19][CH:18]=1

Participants

5

Reactant 2

HCID 3283Diethyl EtherHCID 20027823HCID 20027823, compound

Product 1

HCID 20027838HCID 20027838, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

In a manner analogous to that described in Example 1a, 4.1 g of 3-neopentyl-1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione are dissolved in 80 ml of ethyl acetate, hydrogenated in the presence of 0.4 g of 5% palladium-on-carbon and worked up. Melting point 141.5°-143° (from diethyl ether).

Sources & evidence

ORD record
ord-468a07abb3ae413c91b529d9a1b95929
Source dataset
uspto-grants-1988_08
Patent number
US04764640

Reaction notes

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