反应详情

A mixed solution of 3-[2-chloro-4-(4-chlorophenyl)-5-oxazolyl]propionic acid (1.43 g), cyclohexylmercaptan (0.6 g) and N,N-dimethylformamide (20 mL) was stirred at 100° C. for 1.5 hrs. The reaction mixture was diluted with water, and washed with diethyl ether. The aqueous layer was acidified with 2N aqueous hydrochloric acid solution, and the mixture was extracted with ethyl acetate. The organic layer was washed successively with water and saturated brine, dried over anhydrous magnesium sulfate and concentrated to give 3-[4-(4-chlorophenyl)-2-(cyclohexylsulfanyl)-5-oxazolyl]propionic acid (0.95 g, yield 52%) as crystals. Recrystallization from ethanol gave colorless prism crystals. melting point: 136–137° C.

1. washwashed with diethyl ether
2. extractionthe mixture was extracted with ethyl acetate
3. washThe organic layer was washed successively with water and saturated brine
4. dry with materialdried over anhydrous magnesium sulfate
5. concentrationconcentrated