反应详情

A solution of 5-Bromo-1H-indole-2-carboxylic acid (commercial, 10.0 g, 41.6 mmol) in methanol (200 ml) was cooled to 0° C. and saturated with HCl (g). The resulting solution was allowed to warm gradually to room temperature overnight. The solvent was removed in vacuo and the residue treated with 0.88 ammonia (500 ml). The resulting solution was extracted with dichloromethane (3-fold 150 ml) and the combined organics dried (magnesium sulphate) and the solvent removed in vacuo to give the required product as a colourless oil (8.35 g).

1. customThe solvent was removed in vacuo
2. additionthe residue treated with 0.88 ammonia (500 ml)
3. extractionThe resulting solution was extracted with dichloromethane (3-fold 150 ml)
4. dry with materialthe combined organics dried (magnesium sulphate)
5. customthe solvent removed in vacuo