反应详情

A round bottom flask was mixed with tert-butyl 1-[4-(trifluoromethyl)phenyl]piperidin-4-ylcarbamate (472 mg, 1.42 mmol) and a solution of 4.0 N HCl in 1,4-dioxane (20 mL). The reaction mixture was allowed to stir at RT for a period of 17.0 hours. After 17.0 hours the reaction mixture was concentrated to dryness to afford a crude solid. The resulting solid was triturated with ether and filtered to give a total of 377 mg of desired product (92% yield). The product was used without further purification.

1. concentrationAfter 17.0 hours the reaction mixture was concentrated to dryness
2. customto afford a crude solid
3. customThe resulting solid was triturated with ether
4. filtrationfiltered