2-(4-Cyano-3-fluoro-phenoxy)-propionic acid tert-butyl ester → (R)-2-(4-Aminomethyl-3-fluoro-phenoxy)-propionic acid tert-butyl ester

HRID 350980Notes

Reaction equation

HRID 350980 reaction equation
[C:1]([O:5][C:6](=[O:19])[C@H:7]([O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]#[N:17])=[C:12]([F:18])[CH:11]=1)[CH3:8])([CH3:4])([CH3:3])[CH3:2].C(OC(=O)C(OC1C=CC(C#N)=C(F)C=1)C)(C)(C)C>>[C:1]([O:5][C:6](=[O:19])[C@H:7]([O:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][NH2:17])=[C:12]([F:18])[CH:11]=1)[CH3:8])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 235293652-(4-Cyano-3-fluoro-phenoxy)-propionic acid tert-butyl esterHCID 60128047(R)-2-(4-Cyano-3-fluoro-phenoxy)-propionic acid tert-butyl ester

Product 1

HCID 60128053(R)-2-(4-Aminomethyl-3-fluoro-phenoxy)-propionic acid tert-butyl ester

Procedure

The compound of Formula (5.0.20) was prepared in a manner analogous to that described in Preparation 10, substituting (R)-2-(4-Cyano-3-fluoro-phenoxy)-propionic acid tert-butyl ester for the corresponding (+)-2-(4-cyano-3-fluoro-phenoxy)-propionic acid tert-butyl ester material.

Workup

  1. customthat described in Preparation 10

Sources & evidence

ORD record
ord-d113e33e2d214176811e9cc8856f3bc8
Source dataset
uspto-grants-2007_02
Patent number
US07183293B2

Reaction notes

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