HRID350983

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2736879

2-[(2H-1,3-Benzodioxol-5-yl)oxy]pyridine-3-carboxylic acid

C13H9NO5

HCID12849335

2-(3-Cyanophenoxy)-3-pyridinecarboxylic acid

C13H8N2O3

HCID18174008

未命名化合物

HCID23529364

未命名化合物

PRODUCTS

生成物

结构：CC(Oc1ccc(CNC(=O)c2cccnc2Oc2cccc(C#N)c2)c(F)c1)C(=O)OC(C)(C)C

HCID23529361

未命名化合物

PROCEDURE

实验过程

The compound of Formula (5.0.25) was prepared in a manner analogous to that described in Preparation 20, substituting 2-(3-cyano-phenoxy)-nicotinic acid and (+)-2-(4-aminomethyl-3-fluoro-phenoxy)-propionic acid tert-butyl ester for the corresponding 2-(benzo-[1,3]-dioxol-5-yloxy)-nicotinic acid and (4-aminomethyl-3-fluoro-phenoxy)-acetic acid methyl ester materials, respectively.

WORKUP

后处理

customthat described in Preparation 20

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-14d58f1b611349469fbd5b246243a589
来源数据集: uspto-grants-2007_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07183293B2
来源说明: uspto-grants-2007_02

反应 SMILES

[C:1]([C:3]1[CH:4]=[C:5]([CH:16]=[CH:17][CH:18]=1)[O:6][C:7]1[N:15]=[CH:14][CH:13]=[CH:12][C:8]=1[C:9]([OH:11])=O)#[N:2].[C:19]([O:23][C:24](=[O:37])[CH:25]([O:27][C:28]1[CH:33]=[CH:32][C:31]([CH2:34][NH2:35])=[C:30]([F:36])[CH:29]=1)[CH3:26])([CH3:22])([CH3:21])[CH3:20].O1C2C=CC(OC3N=CC=CC=3C(O)=O)=CC=2OC1.COC(=O)COC1C=CC(CN)=C(F)C=1>>[C:19]([O:23][C:24](=[O:37])[CH:25]([O:27][C:28]1[CH:33]=[CH:32][C:31]([CH2:34][NH:35][C:9]([C:8]2[C:7]([O:6][C:5]3[CH:16]=[CH:17][CH:18]=[C:3]([C:1]#[N:2])[CH:4]=3)=[N:15][CH:14]=[CH:13][CH:12]=2)=[O:11])=[C:30]([F:36])[CH:29]=1)[CH3:26])([CH3:20])([CH3:21])[CH3:22]