HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(1,3-Benzodioxol-5-yloxy)pyridine-3-carboxylic acid → (+)-2-[3-Fluoro-4-({[2-(3-cyano-phenoxy)-pyridine-3-carbonyl]-amino}-methyl)-phenoxy]-propionic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(1,3-Benzodioxol-5-yloxy)pyridine-3-carboxylic acid | HCID 2736879 | — |
| Reactant | 2-(3-Cyano-phenoxy)-nicotinic acid | HCID 12849335 | — |
| Reactant | Methyl 2-[4-(aminomethyl)-3-fluorophenoxy]acetate | HCID 18174008 | — |
| Reactant | (+)-2-(4-Aminomethyl-3-fluoro-phenoxy)-propionic acid tert-butyl ester | HCID 23529364 | — |
| Product | (+)-2-[3-Fluoro-4-({[2-(3-cyano-phenoxy)-pyridine-3-carbonyl]-amino}-methyl)-phenoxy]-propionic acid tert-butyl ester | HCID 23529361 | — |
Reaction Steps
The compound of Formula (5.0.25) was prepared in a manner analogous to that described in Preparation 20, substituting 2-(3-cyano-phenoxy)-nicotinic acid and (+)-2-(4-aminomethyl-3-fluoro-phenoxy)-propionic acid tert-butyl ester for the corresponding 2-(benzo-[1,3]-dioxol-5-yloxy)-nicotinic acid and (4-aminomethyl-3-fluoro-phenoxy)-acetic acid methyl ester materials, respectively.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07183293B2 |
| Source dataset | uspto-grants-2007_02 |
| ORD ID | ord-14d58f1b611349469fbd5b246243a589 |
| Source note | uspto-grants-2007_02 |