Dichloromethane → HCID 73989415, compound

HRID 351040Notes

Reaction equation

HRID 351040 reaction equation
[CH2:1]([NH:9][S:10]([C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][C:21]([OH:23])=O)[CH:16]=[CH:17][CH:18]=1)(=[O:12])=[O:11])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[Cl:24]CCl>CN(C)C=O>[CH2:1]([NH:9][S:10]([C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][C:21]([Cl:24])=[O:23])[CH:16]=[CH:17][CH:18]=1)(=[O:12])=[O:11])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 67019613HCID 67019613, compound

Product 1

HCID 73989415HCID 73989415, compoundYield 101.6%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideCatalyst

Conditions

Temperature
40 °C

Procedure

To a suspension of 3-(3-phenethylsulfamoyl-phenyl)-acrylic acid (5h) (0.15 g, 0.45 mmol) in dichloromethane (2.0 ml) oxalyl chloride (0.14 ml, 1.57 mmol) and one drop of dimethylformamide were added. The reaction mixture was stirred at 40° C. for one hour and concentrated under reduced pressure to give crude title compound (0.16 g).

Workup

  1. additionwere added
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-c599308e2f404e2c997cf1136e7261e0
Source dataset
uspto-grants-2007_02
Patent number
US07183298B2

Reaction notes

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