Dichloromethane → HCID 73989418, compound

HRID 351043Notes

Reaction equation

HRID 351043 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:9][S:10]([C:13]2[CH:14]=[C:15]([CH:19]=[CH:20][C:21]([OH:23])=O)[CH:16]=[CH:17][CH:18]=2)(=[O:12])=[O:11])[CH:6]=[CH:7][CH:8]=1.[Cl:24]CCl>CN(C)C=O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:9][S:10]([C:13]2[CH:14]=[C:15]([CH:19]=[CH:20][C:21]([Cl:24])=[O:23])[CH:16]=[CH:17][CH:18]=2)(=[O:12])=[O:11])[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 67019645HCID 67019645, compound

Product 1

HCID 73989418HCID 73989418, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideCatalyst

Conditions

Temperature
40 °C

Procedure

To a suspension of 3-[3-(3-methoxyphenyl-sulfamoyl)-phenyl]-acrylic acid (5i) (0.38 g, 1.14 mmol) in dichloromethane (4 ml) oxalyl chloride (0.3 ml, 3.43 mmol) and one drop of dimethylformamide were added. The reaction mixture was stirred at 40° C. for one hour and concentrated under reduced pressure to give crude title compound (0.40 g, 100%).

Workup

  1. additionwere added
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-2c60c35f1c1d448ba63f7449720838ff
Source dataset
uspto-grants-2007_02
Patent number
US07183298B2

Reaction notes

Loading…