Dichloromethane → HCID 73989424, compound

HRID 351052Notes

Reaction equation

HRID 351052 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][NH:8][S:9]([C:12]2[CH:13]=[C:14]([CH:18]=[CH:19][C:20]([OH:22])=O)[CH:15]=[CH:16][CH:17]=2)(=[O:11])=[O:10])[CH:2]=1.[Cl:23]CCl>CN(C)C=O>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][NH:8][S:9]([C:12]2[CH:13]=[C:14]([CH:18]=[CH:19][C:20]([Cl:23])=[O:22])[CH:15]=[CH:16][CH:17]=2)(=[O:11])=[O:10])[CH:2]=1

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 67019629HCID 67019629, compound

Product 1

HCID 73989424HCID 73989424, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideCatalyst

Conditions

Temperature
40 °C

Procedure

To a suspension of 3-{3-[(pyridin-3-ylmethyl)-sulfamoyl]-phenyl}-acrylic acid (15b) (0.28 g, 0.88 mmol) in dichloromethane (3.5 ml) oxalyl chloride (0.23 ml, 2.64 mmol) and one drop of dimethylformamide were added. The reaction mixture was stirred at 40° C. for one hour and concentrated under reduced pressure to give crude title compound (0.29 g, 98%).

Workup

  1. additionwere added
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-8783e348dc3543e39e5ef584a7762f87
Source dataset
uspto-grants-2007_02
Patent number
US07183298B2

Reaction notes

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