3-Chloro-4-fluorobenzenesulphonyl chloride → HCID 178513462, compound

HRID 351129Notes

Reaction equation

HRID 351129 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[F:12])[C:6]([NH2:8])=[NH:7].[Cl:13][C:14]1[CH:15]=[C:16]([S:21](Cl)(=[O:23])=[O:22])[CH:17]=[CH:18][C:19]=1[F:20]>>[Cl:13][C:14]1[CH:15]=[C:16]([S:21]([NH:7][C:6](=[NH:8])[C:5]2[CH:9]=[CH:10][C:11]([F:12])=[C:3]([Cl:2])[CH:4]=2)(=[O:22])=[O:23])[CH:17]=[CH:18][C:19]=1[F:20]

Participants

3

Reactant 2

HCID 1452223-Chloro-4-fluorobenzenesulphonyl chlorideHCID 27301603-Chloro-4-fluorobenzene-1-carboximidamide--hydrogen chloride (1/1)

Product 1

HCID 178513462HCID 178513462, compound

Procedure

A mixture of 3-chloro-4-fluorobenzamidine hydrochloride (0.025 g, 0.133 mmol) and 3-chloro-4-fluorophenyl sulfonylchloride (0.0304 g, 0.133 mmol); the title compound is prepared essentially as described in Example 115. ES Positive Ion MS [M+H]+ ions observed: m/z 365 (35Cl, 35Cl), m/z 367 (35Cl, 37Cl) and m/z 369 (37Cl, 37Cl).

Sources & evidence

ORD record
ord-14e5aae1ba484591954668a36bf67e5e
Source dataset
uspto-grants-2007_02
Patent number
US07183320B2

Reaction notes

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