反应详情

The acid (1 mmol) obtained in Step A is dissolved in acetone. The temperature of the reaction mixture is lowered with the aid of an ice bath, and triethylamine (1.5 mmol) and then ethyl chloroformate (1.5 mmol) are added. After stirring for 15 minutes, sodium azide (1.5 mmol), previously dissolved in water (1 ml of water per 400 mg of sodium azide), is added and stirring is again carried out for 10 minutes. The mixture is extracted with ethyl acetate, and the organic phase is then washed with water, dried over magnesium sulphate and evaporated to dryness. The azide obtained is used, without additional purification, in the following Step.

1. customThe temperature of the reaction mixture is lowered with the aid of an ice bath
2. additionis added
3. stirringstirring
4. waitis again carried out for 10 minutes
5. extractionThe mixture is extracted with ethyl acetate
6. washthe organic phase is then washed with water
7. dry with materialdried over magnesium sulphate
8. customevaporated to dryness