反应详情

Using General Procedure G: 7-methoxy-2-tetralone (60 mg, 0.34 mmol), N-(2-nitrobenzenesulfonyl)-N-(2-pyridinylmethyl)-1,4-benzenedimethanamine (100 mg, 0.24 mmol) and NaBH3CN (59 mg, 0.94 mmol) in MeOH (3 mL), trimethyl orthoformate (1.7 mL) and acetic acid (3 drops) were reacted for 3.5 hours. Following work-up, the crude material was purified by chromatography on silica gel (CH2Cl2/MeOH/NH4OH 98:1:1) to give the desired product (71 mg, 52%) as a yellow foam.

1. customthe crude material was purified by chromatography on silica gel (CH2Cl2/MeOH/NH4OH 98:1:1)