HCID 21091167, compound → HCID 21091171, compound

HRID 351196Notes

Reaction equation

HRID 351196 reaction equation
[C:1]([C:4]1[CH:8]=[C:7]([C:9]2[CH:25]=[CH:24][C:12]([O:13][CH2:14][CH2:15][NH:16][C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[CH:11][CH:10]=2)[N:6]([C:26]2[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][CH:27]=2)[N:5]=1)([CH3:3])=[CH2:2]>O1CCCC1.CO.[Pd]>[CH:1]([C:4]1[CH:8]=[C:7]([C:9]2[CH:10]=[CH:11][C:12]([O:13][CH2:14][CH2:15][NH:16][C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:20])[CH3:21])=[CH:24][CH:25]=2)[N:6]([C:26]2[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][CH:27]=2)[N:5]=1)([CH3:3])[CH3:2]

Participants

5

Reactant 1

HCID 21091167HCID 21091167, compound

Product 1

HCID 21091171HCID 21091171, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 10% Pd-C 50% wet (65 mg) and tert-butyl 2-{4-[3-isopropenyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl]phenoxy}ethylcarbamate obtained by Example 7 (645 mg) in tetrahydrofuran (2 ml) and methanol (4 ml) was hydrogenated under H2 1 atm at room temperature for 3 hrs.

Workup

  1. customat room temperature
  2. customfor 3 hrs

Sources & evidence

ORD record
ord-3c8f2f4d6a934743baed5076273ddcf5
Source dataset
uspto-grants-2007_02
Patent number
US07183306B2

Reaction notes

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