4-Methoxyphenylhydrazine hydrochloride → HCID 21090991, compound

HRID 351197Notes

Reaction equation

HRID 351197 reaction equation
[Na].Cl.[CH3:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][NH2:12])=[CH:7][CH:6]=1.[CH2:13]([O:20][C:21]1[CH:26]=[CH:25][C:24]([CH:27]=[CH:28][C:29]#[N:30])=[CH:23][CH:22]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C(O)C>[CH2:13]([O:20][C:21]1[CH:22]=[CH:23][C:24]([CH:27]2[N:11]([C:8]3[CH:9]=[CH:10][C:5]([O:4][CH3:3])=[CH:6][CH:7]=3)[N:12]=[C:29]([NH2:30])[CH2:28]2)=[CH:25][CH:26]=1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Participants

5

Reactant 3

HCID 27239044-Methoxyphenylhydrazine hydrochlorideHCID 39556983-(4-Benzyloxyphenyl)acrylonitrileHCID 5360545Sodium2×

Product 1

HCID 21090991HCID 21090991, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Sodium (3.19 g) was added portionwise to ethanol (160 ml) After all sodium was dissolved, 4-methoxyphenylhydrazine hydrochloride (14.5 g) was added in one portion to the solution. The mixture was stirred at room temperature for 10 min. To this mixture was added 3-(4-benzyloxyphenyl)acrylonitrile (16.3 g) in one portion, and the mixture was refluxed for 3 days.

Workup

  1. dissolutionwas dissolved
  2. temperaturethe mixture was refluxed for 3 days

Sources & evidence

ORD record
ord-ddf6695b381549e2b32c5217afe4e09e
Source dataset
uspto-grants-2007_02
Patent number
US07183306B2

Reaction notes

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