Hydrochloric Acid → 4-[3-Chloro-1-(4-methoxyphenyl)-1H-pyrazol-5-yl]phenol

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-chloro-5-[4-(methoxymethoxy)-phenyl]-1-(4-methoxyphenyl)-1H-pyrazole obtained by Example 21 (2.35 g) in tetrahydrofuran (10 ml) and methanol (10 ml) was added 36% hydrochloric acid (0.34 ml) . The reaction mixture was stirred at room temperature for 1 hr, at 50° C. for 1.5 hrs, and at 60° C. for 1.5 hrs.

Provenance & Evidence