Hydrochloric Acid → HCID 21090957, compound

HRID 351214Notes

Reaction equation

HRID 351214 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:13]([C:14]3[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[CH:16][CH:15]=3)[N:12]=[C:11]([C:22]([F:25])([F:24])[F:23])[CH:10]=2)=[CH:5][CH:4]=1.[ClH:26]>C(O)C>[ClH:26].[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[N:13]([C:14]3[CH:21]=[CH:20][C:17]([CH2:18][NH2:19])=[CH:16][CH:15]=3)[N:12]=[C:11]([C:22]([F:25])([F:23])[F:24])[CH:10]=2)=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21090956HCID 21090956, compound

Product 1

HCID 21090957HCID 21090957, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 4-[5-(4-methoxyphenyl)-3-(trifluoro-methyl)-1H-pyrazol-1-yl]benzonitrile obtained by Example 69 (400 mg) and 50% wet pd/C (400 mg) in ethanol (10 ml) and 1N hydrochloric acid (1.2 ml) was stirred under hydrogen atmosphere for 8 hrs.

Sources & evidence

ORD record
ord-1375ff84fd3747a9add0052a9eef724d
Source dataset
uspto-grants-2007_02
Patent number
US07183306B2

Reaction notes

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