Sodium Acetate → HCID 10387407, compound

Participants

Reaction Conditions

Reaction Steps

2-{4-[1-(4-Methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]phenoxy}ethanamine hydrochloride obtained by Example 74 (400 g) and sodium acetate (159 g) was dissolved in a mixture of N,N-dimethylformamide (1.4 L) and water (0.52 L) at 50° C. A solution of potassium cyanate (157 g) in water (520 ml) was added dropwise to the solution over 15 min at 38–40° C. The whole solution was stirred at 50° C. for 2 hrs.

Provenance & Evidence