Sodium Acetate → HCID 10387407, compound

HRID 351218Notes

Reaction equation

HRID 351218 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:14]([C:15]3[CH:24]=[CH:23][C:18]([O:19][CH2:20][CH2:21][NH2:22])=[CH:17][CH:16]=3)=[CH:13][C:12]([C:25]([F:28])([F:27])[F:26])=[N:11]2)=[CH:6][CH:5]=1.C([O-])(=O)C.[Na+].[O-:34][C:35]#[N:36].[K+]>CN(C)C=O.O>[CH3:2][O:3][C:4]1[CH:5]=[CH:6][C:7]([N:10]2[C:14]([C:15]3[CH:24]=[CH:23][C:18]([O:19][CH2:20][CH2:21][NH:22][C:35]([NH2:36])=[O:34])=[CH:17][CH:16]=3)=[CH:13][C:12]([C:25]([F:28])([F:26])[F:27])=[N:11]2)=[CH:8][CH:9]=1

Participants

6

Reactant 3

HCID 517045Sodium AcetateHCID 11378442Potassium cyanateHCID 21090728HCID 21090728, compound

Product 1

HCID 10387407HCID 10387407, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 6228DimethylformamideSolvent

Conditions

Temperature
50 °C

Procedure

2-{4-[1-(4-Methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]phenoxy}ethanamine hydrochloride obtained by Example 74 (400 g) and sodium acetate (159 g) was dissolved in a mixture of N,N-dimethylformamide (1.4 L) and water (0.52 L) at 50° C. A solution of potassium cyanate (157 g) in water (520 ml) was added dropwise to the solution over 15 min at 38–40° C. The whole solution was stirred at 50° C. for 2 hrs.

Sources & evidence

ORD record
ord-ac00c75441f646b59cc85dc6ab87e361
Source dataset
uspto-grants-2007_02
Patent number
US07183306B2

Reaction notes

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