(4-(Benzyloxy)phenyl)hydrazine monohydrochloride → 2-{4-[1-(4-Benzyloxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]phenoxyl}ethanamine hydrochloride

HRID 351221Notes

Reaction equation

HRID 351221 reaction equation
[ClH:1].[CH2:2]([O:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16][NH2:17])=[CH:12][CH:11]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[F:18][C:19]([F:43])([F:42])[C:20](=O)[CH2:21][C:22]([C:24]1[CH:40]=[CH:39][C:27]([O:28][CH2:29][CH2:30][NH:31]C(=O)OC(C)(C)C)=[CH:26][CH:25]=1)=O>>[ClH:1].[CH2:2]([O:9][C:10]1[CH:11]=[CH:12][C:13]([N:16]2[C:22]([C:24]3[CH:40]=[CH:39][C:27]([O:28][CH2:29][CH2:30][NH2:31])=[CH:26][CH:25]=3)=[CH:21][C:20]([C:19]([F:18])([F:42])[F:43])=[N:17]2)=[CH:14][CH:15]=1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 3016725(4-(Benzyloxy)phenyl)hydrazine monohydrochlorideHCID 21091173tert-Butyl 2-[4-(4,4,4-trifluoro-3-oxobutanoyl)-phenoxy]ethylcarbamate

Product 1

HCID 210907072-{4-[1-(4-Benzyloxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]phenoxyl}ethanamine hydrochlorideYield 87.5%

Procedure

The title compound (12.9 g, 87.5%) was prepared from 1-[4-(benzyloxy)phenyl]hydrazine hydrochloride obtained by Example 79-1 and tert-butyl 2-[4-(4,4,4-trifluoro-3-oxobutanoyl)phenoxy]ethylcarbamate obtained by Example 78-2 in a similar manner to that of Example 78-3.

Sources & evidence

ORD record
ord-c83a95c4f2d84e6ca5e1b908c3261342
Source dataset
uspto-grants-2007_02
Patent number
US07183306B2

Reaction notes

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