(4-(Benzyloxy)phenyl)hydrazine monohydrochloride → 2-{4-[1-(4-Benzyloxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]phenoxyl}ethanamine hydrochloride

Participants

Role	Name	HCID	Charge
Reactant	(4-(Benzyloxy)phenyl)hydrazine monohydrochloride	HCID 3016725	—
Reactant	tert-Butyl 2-[4-(4,4,4-trifluoro-3-oxobutanoyl)-phenoxy]ethylcarbamate	HCID 21091173	—
Product	2-{4-[1-(4-Benzyloxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]phenoxyl}ethanamine hydrochloride	HCID 21090707	87.5%

Reaction Steps

The title compound (12.9 g, 87.5%) was prepared from 1-[4-(benzyloxy)phenyl]hydrazine hydrochloride obtained by Example 79-1 and tert-butyl 2-[4-(4,4,4-trifluoro-3-oxobutanoyl)phenoxy]ethylcarbamate obtained by Example 78-2 in a similar manner to that of Example 78-3.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07183306B2
Source dataset	uspto-grants-2007_02
ORD ID	ord-c83a95c4f2d84e6ca5e1b908c3261342
Source note	uspto-grants-2007_02